Age (<i>p</i> < 0.001), MGMT methylation (<i>p</i> = 0.017), and smaller residual tumor volume post-recurrence surgery (<i>p</i> = 0.008) were also associated with longer survival.<h4>Conclusions</h4>CWI did not significantly improve OS or SAR in recurrent GBM patients. This evidence concerns the gene MGMT and glioblastoma.