<h4>Objectives</h4>To determine whether genetic variation in peroxisome proliferator-activated receptor gamma (PPARγ) is associated with mortality across corticosteroid exposure strata in pediatric septic shock.<h4>Design</h4>Multicenter prospective observational study.<h4>Setting</h4>PICUs at multiple U.S. hospitals.<h4>Patients</h4>Children 1 week to 10 years old meeting consensus criteria for septic shock.<h4>Interventions</h4>None.<h4>Measurements and main results</h4>Genomic DNA was genotyped for two PPARγ single nucleotide variants (SNVs; rs10865710 and rs1801282) using TaqMan assays. This evidence concerns the gene PPARG and Shock.