NR4A2 and Cognitive impairment: This study investigated whether the Nurr1 agonist, amodiaquine (AQ), can enhance synaptic plasticity and alleviate cognitive deficits caused by CCH.<h4>Methods</h4>A CCH rat model was created using the bilateral common carotid arterial occlusion method, followed by a 2-week AQ treatment (20 mg/kg, every 12 h, through intraperitoneal injection).