EPCAM and head and neck squamous cell carcinoma: Epithelial cell adhesion molecule (EpCAM/CD326) is substantially overexpressed in HNSCC representing a potential target for fluorescence-guided delineation of HNSCC.<h4>Materials and methods</h4>EpCAM expression was assessed in vitro on squamous cell carcinomas of the upper aerodigestive tract (SCC-UADT) and fibroblasts employing immunostaining with anti-EpCAM antibodies VU1D9 and MT201/adecatumumab (clinically validated).