<h4>Background</h4>Brugada phenocopy is a reversible Brugada pattern on an electrocardiogram (ECG) caused by identifiable clinical conditions (such as fever, electrolyte abnormalities, or drug exposure) in patients without true congenital Brugada syndrome, which is an inherited arrhythmogenic disorder often associated with SCN5A mutations.<h4>Case summary</h4>A 53-year-old man with metastatic myeloid sarcoma presented with high-grade fever and chest pain. This evidence concerns the gene SCN5A and myeloid sarcoma.