Salidroside, a bioactive glycoside derived from <i>Rhodiola rosea</i>, exhibits neuroprotective and antioxidative properties; however, its effects on mitochondrial dysfunction and APP processing in AD remain to be fully elucidated.<h4>Methods and study design</h4>We employed both <i>in vivo</i> and <i>in vitro</i> models to evaluate the neuroprotective potential of salidroside. This evidence concerns the gene APP and Alzheimer disease.