Among other clinicopathological parameters, overexpression was more frequently observed in males (38.1% vs 14.3% in females), alcohol users (57.1% of exclusive alcohol users), and tongue carcinomas (57.1% of tongue cases); however, these associations were not statistically significant.<h4>Conclusion</h4> EpCAM overexpression was detected in approximately 28.6% of OSCC cases in this Northeast Indian cohort. Here, EPCAM is linked to tongue cancer.