Functionally, knockdown of IL1RN significantly enhanced the cytotoxicity of T cells against pancreatic cancer cells <i>in vitro</i>.<h4>Conclusion</h4>We constructed a novel TRG-based prognostic signature that can serve as an auxiliary tool for clinical prognostic evaluation in pancreatic cancer. The gene discussed is IL1RN; the disease is familial pancreatic carcinoma.