Conditioned-medium and co-culture experiments, together with flow cytometry analysis of M2-associated surface markers were used to determine the impact of STC1 on macrophage polarization and the reciprocal effects of polarized macrophages on CRC cell behavior.<h4>Results</h4>STC1 was significantly upregulated in CRC, and high STC1 expression was associated with worse overall and disease-free survival. Here, STC1 is linked to colorectal carcinoma.