We examined the clinical relevance and mechanistic function of stanniocalcin-1 (STC1) in CRC, with emphasis on macrophage polarization.<h4>Methods</h4>STC1 expression patterns, prognostic value, and associated pathways were analyzed in TCGA and GEO CRC datasets, followed by KEGG enrichment. Here, STC1 is linked to colorectal carcinoma.