CLN3 and Cognitive impairment: The neuronal function of CLN3 is unknown, and the pathomechanisms leading to cognitive impairment are poorly understood hindering the development of targeted therapies.<h4>Methods</h4>Whole-cell patch clamp and high-density microelectrode array recordings were performed in acute brain slices from Cln3<sup>Δex7/8</sup> mice to assess synaptic properties, intrinsic excitability, and network activity.