Compared with non-ED patients, ED patients had a significantly higher proportion of the CD34 and HLA-DR double-negative immunophenotype (CD34(-)/HLA-DR(-)) (71.4% <i>vs</i> 30.0%, <i>P</i><0.001), a higher incidence of coagulopathy (80.0% <i>vs</i> 27.5%, <i>P</i><0.001), and a higher incidence of TET2 mutations (40.0% <i>vs</i> 19.1%, <i>P</i>=0.004). This evidence concerns the gene TET2 and blood coagulation disease.