Both CD4<sup>+</sup>PD-1<sup>+</sup>TIGIT<sup>+</sup> and CD8<sup>+</sup>PD-1<sup>+</sup>TIGIT<sup>+</sup> cells increased after 3 months of anti-TNF treatment in RA and AS.<h4>Conclusion</h4>CD8<sup>+</sup>PD-1<sup>+</sup>TIGIT<sup>+</sup> T-cell expression is elevated in SjD and RA compared with HV and AS. The gene discussed is CD8A; the disease is rheumatoid arthritis.