The main evaluation indicators included clinical joint manifestations (arthritis index, paw volume), anti-inflammatory indicators (TNF-α, IL-1β, IL-6, IL-10), and joint-protective indicators (Histological score, MMP-9, RANKL, OPG).<h4>Results</h4>The meta-analysis demonstrated that sinomenine significantly improved arthritis index and reduced paw volume. Here, IL6 is linked to arthritic joint disease.