TXNIP and Salla disease: This indicates coordinated activation of a T-B-myeloid communication axis, which was absent in SD patients.<h4>Conclusions</h4>This integrative spatiotemporal single-cell analysis reveals that effective ICB responses in CRC are associated with coordinated activation of cytotoxic T cells, TXNIP-associated transcriptional changes in B cells, and strengthening of CXCL-centered immune communication networks.