<h4>Introduction</h4>Over 90% of pancreatic adenocarcinoma (PDAC) has a <i>KRAS</i> mutation, 98% of which are single-base missense variants occurring at codon 12 (G12), codon 13 (G13), or codon 61 (Q61), with numerous studies demonstrating their clinical utility. The gene discussed is KRAS; the disease is pancreatic adenocarcinoma.