Furthermore, analyses of conditioned medium, EV isolation and characterization, and endothelial tube formation assays demonstrated that EVs derived from CFPAC-1 cells carrying <i>KRT7</i> enhanced PAAD angiogenesis through VEGF/VEGFR signaling.<h4>Conclusion</h4>A robust prognostic model was established that connects overall survival with immune status in patients with PAAD. Here, KRT7 is linked to pancreatic adenocarcinoma.