TSLP and Pilonidal sinus: <h4>Objective</h4>To investigate the predictive value of serum citrullinated histone H3 (CitH3) and thymic stromal lymphopoietin (TSLP) for postoperative wound healing outcomes in patients with pilonidal sinus (PS), and to construct a nomogram-based risk prediction model.<h4>Methods</h4>This prospective observational study enrolled 181 patients with PS who underwent Bascom cleft lift between November 2022 and August 2025.