Although the number of studies analyzing GPX2 in cancer is still limited, data suggesting a role of altered GPX2 expression in various cancer types are accumulatin.<h4>Methods</h4>To better comprehend the role of GPX2 expression in cancer, GPX2 was analyzed by immunohistochemistry on tissue microarrays containing 18,555 samples from 148 different tumor types.<h4>Results</h4>A total of 95 of 148 tumor categories showed GPX2 expression in at least one case, and 61 tumor categories contained at least one strongly positive case. Here, GPX2 is linked to cancer.