This study aims to analyze the specific expression of three matrix metalloproteinases (MMP-3, MMP-9, and MMP-14) to better understand the molecular mechanisms underlying the invasiveness of different skin cancer subtypes.<h4>Methods</h4>The study involved 30 patients aged between 40 and 50 years: 10 diagnosed with BCC, 10 with SCC, and 10 with melanoma. This evidence concerns the gene MMP3 and skin cancer.