C5orf46 and cancer: The aim of the study is to explore the function of the C5orf46 gene in human pan-cancer, including kidney renal clear cell carcinoma (KIRC), for potential clinical application.<h4>Methods</h4>The study started with the physicochemical properties of C5orf46, then the gene expression as well as alteration patterns in diverse cancers, followed by its post-transcription modulation, and then survival analysis.