This study aimed to evaluate the diagnostic value of serum leucine-rich <i>α</i>-2 glycoprotein 1 (LRG1) in NEC.<h4>Methods</h4>LRG1 was identified through an integrative bioinformatics analysis by intersecting differentially expressed genes from two Gene Expression Omnibus datasets (GSE46619 and GSE64801) with the Secreted Protein Database. Here, LRG1 is linked to necrotizing enterocolitis.