From the haplotype analysis, the G-CT haplotype was significantly different, with an OR value of 2.57 (1.33-4.96, p=0.0057).<h4>Conclusions</h4><i>KISS1</i> rs4889 and rs5780218 polymorphisms, as well as the G-CT haplotype, are associated with increased odds of PCOS in Indonesian women. Here, KISS1 is linked to polycystic ovary syndrome.