This study aimed to investigate the association between dietary oxidative balance and renal impairment in patients with diabetes and to conduct exploratory <i>in vitro</i> experiments examining whether selected nutrients modulate AKT phosphorylation under high-glucose conditions.<h4>Methods</h4>Data from diabetic participants in the National Health and Nutrition Examination Survey (NHANES) 1999-2020 were analyzed. This evidence concerns the gene AKT1 and diabetes mellitus.