Although the Trim and Fill adjustment did not alter the direction of findings, the overall results should be interpreted with caution.<h4>Conclusion</h4>Inhibition of ferroptosis is a promising preclinical strategy to mitigate CI-AKI, with restoration of the System Xc-/GSH/GPX4 axis emerging as the primary mechanistic driver of renoprotection. Here, GPX4 is linked to acute kidney injury.