DAPK1 and acute kidney injury: DAPK1 knockdown enhanced apoptosis, ROS, and membrane vesicle inhibition, which was offset by MAP1B overexpression.<h4>Conclusions</h4>NTN1 facilitates cell membrane blebbing to induce autophagy via regulating MAP1B and DAPK1, thereby alleviating LPS-induced AKI <i>in vitro</i>.