RGS9BP and retinal degeneration: Notably, <i>Rgs9bp</i>, traditionally linked to cone-specific bradyopsia, exhibited hyper-editing in rod-dominant RP models, suggesting a broader role in retinal degeneration.<h4>Conclusions</h4>Our study reveals that A-to-I RNA editing is dynamically regulated during retinal development and profoundly altered in RP, implicating RNA editing as a novel layer of gene regulation in inherited retinal diseases.