<h4>Background</h4>The role of scavenger receptor class B type 1 (SR-B1) in breast cancer remains largely unknown.<h4>Objective</h4>This study aimed to investigate the effects of SR-B1 on breast cancer cell proliferation, migration, and invasion and to elucidate the underlying mechanisms.<h4>Methods</h4>Two breast cancer cell lines, MDA-MB-231 and MCF-7, were used in this study. The gene discussed is SCARB1; the disease is breast carcinoma.