Multivariate analysis ultimately identified 7 independent predictors of postoperative cerebral edema progression: increased age (adjusted odds ratio [aOR] = 1.02/yr), lower admission Glasgow Coma Scale score (aOR = 0.86/point), larger volume of cerebral contusion/hematoma (aOR = 1.06/10 mL), greater midline shift (aOR = 1.12/mm), higher maximum intracranial pressure within 24 hours postoperatively (aOR = 1.11/mm Hg), lower serum sodium level within 24 hours postoperatively (aOR = 0.91/mmol/L), and elevated C-reactive protein level (aOR = 1.03/10 mg/L). This evidence concerns the gene CRP and brain edema.