While their fasting levels have been extensively studied, little is known about their postprandial dynamics, and it is generally assumed that their concentration is unaffected by food intake.<h4>Objective</h4>To evaluate the postprandial responses of leptin and adiponectin following two standardized meals differing in macronutrient composition, in adults with and without obesity.<h4>Methods</h4>In 79 adults (43 women, 36 men; 47% with obesity), we investigated whether meal composition influences adipokine responses. This evidence concerns the gene ADIPOQ and obesity disorder.