Molecular docking was performed to evaluate the binding affinities between the anesthetics and the core targets.<h4>Results</h4>Two core targets, MMP9 (Matrix Metallopeptidase 9) and HPSE (Heparanase), were identified as significantly associated with sevoflurane and propofol in T2DM. This evidence concerns the gene MMP9 and type 2 diabetes mellitus.