Consistent with this, <i>Grn</i> <sup>-/-</sup> mice displayed markedly reduced IL-1β production in serum and paw joints, and attenuated bone erosion in the STA-induced RA model, indicating altered NLRP3 inflammasome signaling in <i>Grn</i> <sup>-/-</sup> mice. The gene discussed is IL1B; the disease is rheumatoid arthritis.