NLRP3 and rheumatoid arthritis: Consistent with this, <i>Grn</i> <sup>-/-</sup> mice displayed markedly reduced IL-1β production in serum and paw joints, and attenuated bone erosion in the STA-induced RA model, indicating altered NLRP3 inflammasome signaling in <i>Grn</i> <sup>-/-</sup> mice.