A similar effect of (R)-methadone in the absence of BMS-986122 was only observed at a dose where respiratory distress was seen.<h4>Conclusions</h4>These findings show that allosteric modulators of the mu opioid receptor such as BMS-986122 can enhance opioid activity that could translate to a safe and effective treatment for chronic neuropathic pain. The gene discussed is OPRM1; the disease is Pain.