Linear mixed effects examined the interactions between SCD, sex, and amyloid positivity in predicting cognitive decline.<h4>Results</h4>SCD+ and A+ individuals exhibited increased global cognition declines (<i>p</i><.05), and A+SCD+ individuals showed the steepest decline in global cognition and function status (<i>p</i><.05). This evidence concerns the gene SCD and Schnyder corneal dystrophy.