Overall, the program was rated as highly acceptable, with participants emphasizing the relevance and applicability of the intervention content within their illness context.<h4>Conclusion</h4>Findings from this preliminary study suggest that the CBT-OP-4 program is a feasible and acceptable psycho-oncological intervention for women with advanced-stage HER2-positive breast cancer receiving palliative care. The gene discussed is ERBB2; the disease is breast carcinoma.