Unweighted and weighted genetic risk scores (GRSs) were constructed, and their interactions with physical activity and sleep were assessed using relative excess risk of interaction (RERI), attributable proportion of interaction (AP) and the interaction of odds ratio (IOR).<h4>Results</h4>We identified important genetic variants associated with obesity: MC4R rs17782313, rs12970134, LEPR rs1137101, and POMC rs6713532. This evidence concerns the gene POMC and obesity due to melanocortin 4 receptor deficiency.