Receiver operating characteristic analysis assessed the predictive value of maternal serum soluble urokinase plasminogen activator receptor levels for neonatal intensive care unit admission.<h4>Results</h4>Maternal serum soluble urokinase plasminogen activator receptor levels, neutrophil-to-lymphocyte ratio, systemic immune-inflammation index, and systemic inflammation response index scores were significantly higher in the preterm premature rupture of membranes group than in controls (p<0.05). The gene discussed is PLAUR; the disease is spontaneous preterm birth.