No correlation was detected between angiopoietin-like protein-3 and systolic blood pressure, body mass index, waist circumference, glucose, homeostatic model assessment insulin resistance, lipids, and inflammatory markers in polycystic ovary syndrome patients with metabolic syndrome.<h4>Conclusion</h4>Angiopoietin-like protein-3 could discriminate metabolic syndrome in polycystic ovary syndrome patients. The gene discussed is ANGPTL3; the disease is metabolic syndrome.