Enrichment analysis revealed that shared biomarkers could influence the development of both obesity and NAFLD via the "ECM-receptor interaction," "Jak-STAT signaling pathway," etc. In lncRNA-miRNA-mRNA network, lncRNAs (NEAT1, MALAT1, and FTX) could simultaneously regulate two shared biomarker via hsa-miR-493-5p. Here, SOAT1 is linked to obesity due to melanocortin 4 receptor deficiency.