<h4>Purpose</h4>To investigate the therapeutic effect and mechanism of Shenge Powder (SGS) on myocardial hypertrophy and cardiac lymphangiogenesis using a transverse aortic constriction (TAC) mouse model and a TNF-α-induced lymphatic endothelial cell (LEC) proliferation model.<h4>Methods</h4>C57BL/6J mice were randomly divided into sham surgery group and model group (Build molds for 2, 4, 6, 8 weeks respectively) for dynamic observation. This evidence concerns the gene TNF and cardiac hypertrophy.