<i>In vitro</i> experiments showed that SGS could promote LEC migration, and upregulate the mRNA and protein expression of VEGFC and VEGFR-3.<h4>Conclusion</h4>Early compensatory cardiac function enhancement and increased lymphangiogenesis were observed in TAC model mouse, followed by cardiac dysfunction, myocardial hypertrophy, myocardial fibrosis, and decreased lymphangiogenesis. Here, VEGFC is linked to Myocardial fibrosis.