FLT4 and Myocardial fibrosis: <i>In vitro</i> experiments showed that SGS could promote LEC migration, and upregulate the mRNA and protein expression of VEGFC and VEGFR-3.<h4>Conclusion</h4>Early compensatory cardiac function enhancement and increased lymphangiogenesis were observed in TAC model mouse, followed by cardiac dysfunction, myocardial hypertrophy, myocardial fibrosis, and decreased lymphangiogenesis.