Finally, LS GLP-1R levels were normalized in obese male rats treated with phentermine plus a control diet or only with a control diet.<h4>Conclusion</h4>In conclusion, the chronic exposure to HFD induces sex differences in LS that could be related to pathological mechanisms observed in obesity and to the efficacy of treatment with GLP-1R agonists. This evidence concerns the gene GLP1R and obesity disorder.