GLP1R and obesity due to melanocortin 4 receptor deficiency: However, the relationship between obesity development and LS dysregulation of the GLP-1/GLP-1R system has been poorly studied.<h4>Methods</h4>We aimed to investigate whether chronic exposure to a high-fat diet (HFD) from weaning to postnatal day (PND) 62 affects the LS GLP-1 system, LS neurotransmitter content, and post-fasting refeeding behavior in rats.