SSs, as small-molecule phytochemicals, exert anticancer effects through the induction of apoptosis, inhibition of metastasis and angiogenesis, alteration of the tumor microenvironment to therapeutic advantage, promotion of the immune response, and other mechanisms that reverse multidrug resistance by modulating the PI3K/Akt pathway.<h4>Conclusion</h4>The combination of SSs with chemotherapeutic agents, given emerging preclinical evidence of small-molecule efficacy, supports the development of new anticancer therapies. This evidence concerns the gene AKT1 and neoplasm.