TP53 and hepatocellular carcinoma: This study aimed to develop and validate a noninvasive ultrasound-based radiomics nomogram integrating variational autoencoder (VAE)-derived deep features to predict p53 expression status, addressing these limitations.<h4>Methods</h4>A retrospective cohort of 172 patients with pathologically confirmed HCC (training cohort: n=120, validation cohort: n=52) who underwent preoperative two-dimensional ultrasound images and had available p53 immunohistochemistry (IHC) results was analyzed.