In CPS grouping, the 5th percentile demonstrated the highest AUC of 0.694, which was improved to 0.752 when combined with tumor size and carcinoembryonic antigen.<h4>Conclusion</h4>Whole-volume ADC histogram parameters of primary tumors hold great potential in predicting PD-L1 expression in PCs. This evidence concerns the gene CD274 and neoplasm.