<h4>Purpose</h4>To assess the possibility of employing whole-volume ADC histogram analysis for predicting programmed cell death ligand 1 (PD-L1) expression in periampullary carcinomas (PCs).<h4>Materials and methods</h4>We retrospectively evaluated imaging records of 65 patients with PC who received pancreaticoduodenectomy in our hospital. This evidence concerns the gene CD274 and pachyonychia congenita.