<h4>Background</h4>MEX3A is an RNA-binding protein implicated in post-transcriptional regulation; however, its role across cancers, particularly in chromophobe renal cell carcinoma (chRCC), remains unclear.<h4>Methods</h4>We performed a comprehensive pan-cancer analysis using TCGA and related databases to evaluate MEX3A expression, prognostic significance, immune associations, genomic alterations, and drug sensitivity. The gene discussed is MEX3A; the disease is cancer.