SRF and metabolic dysfunction-associated steatotic liver disease: Critically, <i>SRF</i> knockdown significantly exacerbated both lipid deposition and cellular senescence in hepatocyte steatosis models, confirming its functional involvement in MASLD pathogenesis.<h4>Conclusion</h4><i>SRF</i> deficiency accelerates hepatocellular senescence and exacerbates MASLD progression.