ALDH2 and hepatocellular carcinoma: Functional experiments demonstrated that knockdown of ALDH2 or AKR1C3 significantly impaired the migration and invasion abilities of Huh7 cells, with a reduction of over 50% in transwell assays (<i>p</i> < 0.05).<h4>Conclusion</h4>This study systematically analyzed the expression characteristics and functional significance of xenobiotic metabolism-related genes in HCC and LC by integrating multiple high-throughput sequencing technologies.