This article also discusses various therapeutic interventions aimed at alleviating psychological symptoms in patients with Type 2 Diabetes Mellitus (T2DM), including pharmacological treatments such as GLP-1 receptor agonists (GLP-1RA) and DPP-4 inhibitors, which not only show potential in regulating blood glucose but also have beneficial effects on mood health. The gene discussed is GLP1R; the disease is diabetes mellitus.