Multivariate analysis and ML-based feature selection consistently identified sex, body mass index (BMI), diabetes mellitus, hypertension, hyperlipidaemia, history of malignancy, intraoperative tachycardia, and postoperative inflammatory markers (neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein (CRP)) as key predictors. The gene discussed is CRP; the disease is hyperlipidemia.