Finally, protein-protein interaction and co-expression analyses were conducted to identify NOP2-interacting and NOP2-correlated genes, which were subjected to functional enrichment analyses to infer potential biological pathways associated with NOP2.<h4>Results</h4>NOP2 mRNA was significantly upregulated in 20 of 33 tumor types compared with normal tissues (|log<sub>2</sub>FC| ≥ 1, q < 0.01), with protein-level overexpression confirmed in most cancers examined (P < 0.001). This evidence concerns the gene NOP2 and cancer.