Carriers of <i>MYH7</i> variants presented with a more obstructive and arrhythmogenic phenotype, demonstrating higher odds of LVOT obstruction (pooled OR range: 1.95-4.30) and a 70% increased risk of incident atrial fibrillation (HR: 1.7, 95% CI: 1.1-2.6). Here, MYH7 is linked to atrial fibrillation.